NAPLEX 2026 — Infectious Diseases Practice Exam 1

Thirty-nine single-best-answer items with five options, eight select-all-that-apply items and three numeric fill-in items. Organism identification from Gram stain, morphology and culture clues; antimicrobial spectrum and the class gaps that matter, including which agents reach which site; resistance mechanisms across MRSA, VRE, ESBL and inducible AmpC; bacterial meningitis and the age-related pathogen risk; community-acquired and hospital-acquired pneumonia, including when to stop therapy; urinary tract infection from asymptomatic bacteriuria through cystitis to pyelonephritis, with the antibiogram and pregnancy decisions they force; skin and soft-tissue infection including cellulitis, abscess, bite wounds and necrotizing infection; Clostridioides difficile across severity strata and its infection-prevention measures; sexually transmitted infections and post-treatment counselling; infective-endocarditis prophylaxis and bloodstream infection, including telling a contaminant from true bacteremia; culture and susceptibility interpretation; antimicrobial pharmacokinetics, safety and monitoring; and the calculations behind a paediatric suspension dose, a vancomycin loading dose and creatinine clearance.